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The new results for estrogen-only pills echo previous data from the same study showing that estrogen-progestin had little effect on older women's overall well-being and quality of life.

The 10,739 women in the latest study, which appeared in yesterday's Archives of Internal Medicine, had all had hysterectomies.

Robert Brunner, the study's lead author and a researcher at the University of Nevada, said that estrogen pills reduced hot flashes in a subgroup of younger study participants but that these women still did not report a better quality of life than placebo users.

"Yes, it's improving some symptoms, but it's also producing some side effects, and that combination ends up resulting in no change" in quality of life, he said.

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