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Earlier hormone therapy trial scared women - but it was wrong!... But then the daily combined drug was thought more convenient because patients did not have to remember which days to take a second pill and because it eliminated a monthly menstrual period. The researcher believes the results might have been different if a different form of estrogen that resembled a normal cycle had been used. Even at the time many doctors considered the WHI study flawed in that the participants were almost all over 60 and so at greater risk of cardiovascular problems anyway. Klaiber says the incidence of heart disease is 12 times higher for women in their 80s than it is in the 50s. Therefore the WHI study began hormone therapy for the first time in women who already had heart disease - not a good idea. Klaiber maintains that earlier studies showing that cyclical hormones are protective against heart disease are probably quite valid. As he says one of the reasons menopausal women were given hormones was because of the gender differential, men have a lot more heart attacks and have them earlier. Klaiber is optimistic that a multi-center trial launched last year by the Pho... Hormone replacement debate therapy cycles back again... He states emphatically that the “everyday” system of progesterone was not tried and tested for its correlation to breast cancer and heart damage. Besides, before WHI, HRT was a cycle treatment, given 10 or 12 days every month. The use of
He goes on to assert that HRT when administered in alternative methods than the “everyday” way, pushes up the safety factor and has positive impact on health. He cited the example of the successful Nurses' Health Study, where women were given HRT at ages 40-50 and more so in intervals. That research had clearly established a heart friendly impact of the treatment.
In response to Klaiber's criticism, Dr. Nieca Goldberg, head of the women's cardiac care unit at Lenox Hill Hospital, New York City, said that his analysis was just old wine in a new bottle, minus any substantiation. She added that for a more concrete understanding, perhaps more studies were needed in the HRT direction, a fact to which Klaiber also agreed.
He hopes that the ongoing study by the Kronos Longevity Research Institute in Phoenix will sufficiently prove that HRT is less harmfu... WHI Trial Seen Flawed; Alternative Hormone Replacement Regimen ......302 Moved Temporarily
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