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This week in the medical journals

...Just being overweight in their 40s increased the participants' risk for dementia in their 60s and 70s by 35 percent.Arterial stiffening - or hardening of the arteries as it was once known - is also influenced by obesity.

Researchers from the University of Colorado in Boulder sounded the alarm about the need for women to stay fit after menopause - a difficult task for women who fight "shifting body mass" and a slowing metabolism when their bodies stop producing estrogen.Writing in Hypertension, Journal of the American Heart Association, the researchers reported that a se...

Judge Rejects Class Action for Monitoring of Prempro Users

...Common Pleas Judge Mark I.

Bernstein noted that both plaintiffs' experts agreed that determining whether a member of the potential class qualified for special medical treatment would require an individual assessment of the risk factors - aside from Bernstein wrote that the class could include as many as 720,000 Pennsylvania women who used the hormone replacement drug.

Because the question of how "In this case of uncontradicted evidence, mostly presented by plaintiff's expert witness, demonstrates that specialized treatment required by a member of the plaintiff class could only be based on an individual assessment of risk factors other than The judge said the plaintiffs hadn't shown they were exposed to a "hazardous substance" - a requirement of demonstrating a medical-monitoring claim - considering evidence that many women are in actual, medical need of "Plaintiff's own expert continues to prescribe the medication characterized as 'hazardous substance,...

HRT Endometrial Cancer Risk Greater for Thin Women

...Women taking Echoing concerns voiced by WHI investigators, Valerie Beral, M.B., the Oxford University epidemiologist who led the Million Woman Study, said, "These new results create a dilemma for women who haven't had a hysterectomy and want to use HRT.

Since breast cancer is much more common than endometrial cancer, combined HRT poses the greatest overall cancer risk." The British study recruited women aged 50 to 64 who were cancer-free at baseline.

Upon entry into the study, the women provided information about their use of HRT and other personal details.

They were classified according to whether they had ever used HRT, age at first and last use, total duration of use, and the name of the preparation last used, and the duration of its use.

The women were followed up for an average of more than three years (through the end of 2002).

There were 1,320 endometrial cancers diagnosed.

Forty-five percent of the women used HRT at baseline.

Of those 320,953 women, 22% used continuous combination therapy, 45% used cyclic combination therapy (estrogen daily with progestin added for 10 to 14 days per month), and 4% used estrogen only HRT.

Another 9% used a synthetic hormone, tibolone, which is not available in the U.S.

Among the findings: For women with a BMI <25 kg/m2, the use of cyclic comb...

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